Cyanobacteria are one of the richest sources of biomedical compounds with extensive therapeutic pharmaceutical applications. The present study to evaluate anti hyperlipidemic activity of marine cyanobacteria Oscillatoria salina in high cholesterol diet induced hyperlipidemic wistar albino rats. Hyperlipidemia was induced in rats by giving high cholesterol diet 2%, sodium cholate 1% and coconut oil 2%, with standard powdered standard animal food for 30 days. The ethanol extract of Oscillatoria salina (1.0) mg/Kg body weight) was orally administered once a day to rats fed with high cholesterol 30 for seven days. Fenofibrate drug were orally administered as reference standard. To assess the total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL) low density lipoprotein (LDL). Hence the present study was undertaken to evaluate the anti hyperlipidemic effect of a marine cyanobacteria, Oscillatoria salina. In this study oral treatment of Oscillatoria salina 1.0 g/Kg per day, significantly reduced the level of serum cholesterol, TG, LDL and VLDL and increase the HDL level in hyperlipidemic rats nearer to standard drug.
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